异丙酚是临床常用的静脉麻醉药,以起效迅速、作用时间短、无蓄积作用等优点被广泛应用于临床麻醉及重症监护镇静。但该药同时具有明显心血管抑制作用,能引起剂量依赖性血压下降,而其具体降压机制错综复杂,主要包括抑制肾素血管紧张素系统,阻断交感神经末梢释放去甲肾上腺素,抑制心肌收缩力,及对外周血管的直接扩张作用等,现综述如下。 Propofol is a commonly used clinical intravenous anesthetic, with rapid onset, short duration of action, no accumulation of advantages such as being widely used in clinical anesthesia and intensive care sedation. But the drug also has obvious cardiovascular inhibition, can cause dose-dependent decline in blood pressure, and its specific antihypertensive mechanism complex, including the inhibition of renin angiotensin system, block the release of norepinephrine sympathetic nerve endings, inhibition of myocardial Contractility, and direct peripheral vascular expansion, are summarized below.