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目的:评价泰素帝联合希罗达方案治疗晚期乳腺癌的疗效和毒副作用。方法:采用泰素帝联合希罗达方案治疗晚期乳腺癌16例,泰素帝75mg/m2第1天,希罗达1000mg/m2第1～14天,2次/d,饭后半小时口服,每3周重复,所有患者均接受2周期以上化疗。结果:有效率68.8%,毒副反应主要为骨髓抑制、消化道反应、手足综合征、皮肤色素沉着等,但均可耐受。结论:泰素帝联合希罗达是治疗晚期乳腺癌的安全、有效方案。
Objective: To evaluate the efficacy and toxicity of taxotere combined with Xeloda in the treatment of advanced breast cancer. Methods: Sixteen patients with advanced breast cancer were treated with Taxotex combined with Xeloda. The first day of Taxotere 75mg / m2, Xeloda 1000mg / m2 1 ~ 14 days, 2 times / d, half an hour after meals orally , Repeated every 3 weeks, all patients received more than 2 cycles of chemotherapy. Results: The effective rate was 68.8%. The main side effects were myelosuppression, digestive tract reaction, hand-foot syndrome, skin pigmentation and so on, but both were tolerable. Conclusion: Taxotere combined with Xeloda is a safe and effective treatment for advanced breast cancer.