前列腺特异抗原(PSA)的发现对于前列腺癌的早期诊断具有里程碑意义。PSA筛选的广泛应用使转移阶段的前列腺癌、早期浸润前列腺癌获得了有效的治疗,并降低了疾病的死亡率。但前列腺其他疾患(如BPH、前列腺炎等)亦可有PSA升高,使得PSA的特异性稍显不足。蛋白组学的发展推动了高特 The discovery of prostate-specific antigen (PSA) is a landmark in the early diagnosis of prostate cancer. The widespread use of PSA screening has led to an effective treatment of prostate cancer, early invasive prostate cancer in the metastatic stage and reduced disease mortality. However, other disorders of the prostate (such as BPH, prostatitis, etc.) may also have elevated PSA, making the PSA slightly less specific. The development of proteomics promoted Gote