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为探讨白细胞介素及白细胞介素受体在选择性IgA缺乏症发病过程中的作用,我们采用间接免疫荧光技术、ELISA夹心法及细胞培养,分别对15例患儿及对照组进行了T细胞亚群、Tac阳性细胞(mIL—2Rα)百分率、SIL—2R及IL—4含量检测。发现SIgAD患儿Tac阳性细胞(mIL—2Rα百分率及血清SIL—2R明显高于对照组,CD4、CD4/CD8、IL—4水平则显著低于对照组。表明血资SIL—2Rα异常增高不但可抑制IL—2的生物活性,还可反馈性地使其它免疫调节相关因子,如IL—4生成受阻。
To explore the role of interleukin and interleukin receptor in the pathogenesis of selective IgA deficiency, we used indirect immunofluorescence technique, ELISA sandwich method and cell culture to detect T cells in 15 children and control group Subpopulations, the percentage of Tac positive cells (mIL-2Rα), SIL-2R and IL-4 levels. It was found that the percentage of the Tac positive cells (the percentage of mIL-2Rα and the level of SIL-2R in serum of SIgAD children were significantly higher than that of the control group, the levels of CD4, CD4 / CD8 and IL-4 were significantly lower than those of the control group Inhibit the biological activity of IL-2, but also feedback to other immune regulatory factors, such as IL-4 blocked.