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Cyr61是CCN(Cyr61、CTGF、NOV)家族中一个重要的成员,Cyr61蛋白具有多种生物学功能,在不同的肿瘤组织中表达量及所起的作用并不相同,同时与胚胎发育、伤口愈合过程密切相关。研究表明,Cyr61在食管癌、胃癌及结肠癌组织中高表达,并参与肿瘤血管的形成及促进肿瘤细胞的增殖、侵袭及转移等多种过程。1 Cyr61蛋白的构成及主要功能CCN家族蛋白有六个成员,分别是CCN1-6,包括VWC因子、胰岛素样生长因子结合蛋白、羧基
Cyr61 is an important member of CCN (Cyr61, CTGF, NOV) family. Cyr61 protein has a variety of biological functions. The expression of Cyr61 in different tumor tissues is not the same as that of Cyr61. Meanwhile, Cyr61 is associated with embryonic development, wound healing The process is closely related. Studies have shown that Cyr61 overexpression in esophageal cancer, gastric cancer and colon cancer tissues, and participate in the formation of tumor blood vessels and promote tumor cell proliferation, invasion and metastasis and other processes. 1 Cyr61 protein composition and main functions CCN family of proteins has six members, namely CCN1-6, including VWC factor, insulin-like growth factor binding protein, carboxyl