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目的:观察健脾化痰清热方药对湿热困脾证2型糖尿病患者血清C反应蛋白(CRP)和白细胞介素6(IL-6)的水平变化。方法:对湿热困脾证的2型糖尿病患者105例,采用随机化方法,按照1∶1比例分为二甲双胍组(对照组)、二甲双胍加健脾化痰清热方药组(试验组),试验终点时间为第12周。在治疗前及试验终点时间分别对两组患者血清中的CRP和IL-6进行测定。比较每组内治疗前后血清中的CRP和IL-6的变化,及两组间试验终点时间血清中的CRP和IL-6变化。血清CPR以速率散射浊度法测定,IL-6采用双抗体夹心ELISA法测定。结果:湿热困脾证的2型糖尿病患者应用药物12周后,试验组血清中的CRP水平由7.78mg/L下降到6.24mg/L,对照组的CRP水平由7.64mg/L下降到5.56mg/L,两组比较P<0.05,各组内治疗前后比较P<0.05;血清中的IL-6水平,试验组由0.79ng/mL下降到0.62ng/mL,治疗组由0.78ng/mL下降到0.49ng/mL,两组比较P<0.05,各组内治疗前后比较P<0.05。结论:二甲双胍加用健脾化痰清热方药更能降低血清中的CRP和IL-6水平。
OBJECTIVE: To observe the changes of serum C-reactive protein (CRP) and interleukin 6 (IL-6) levels in type 2 diabetes mellitus patients with damp-heat and spleen-intoxicant syndromes. Methods: 105 cases of Type 2 diabetes mellitus with dampness and spleen syndrome were randomized and divided into metformin group (control group), metformin plus Jianpi Huayu Qingre Formula group (test group) in a 1:1 ratio. The time is week 12. The CRP and IL-6 levels in the serum of the two groups were measured before and at the end of the treatment period. Changes in serum CRP and IL-6 before and after treatment in each group were compared, and changes in serum CRP and IL-6 at the end of the trial between the two groups. Serum CPR was measured by a rate-scattering turbidimetric assay and IL-6 was measured by a double-antibody sandwich ELISA. RESULTS: After 12 weeks of drug administration in type 2 diabetes patients with damp-heat and spleen-stomach syndrome, the serum CRP level in the test group decreased from 7.78 mg/L to 6.24 mg/L, and the CRP level in the control group decreased from 7.64 mg/L to 5.56 mg /L, P<0.05 for the two groups, P<0.05 before and after treatment in each group; IL-6 levels in serum decreased from 0.79 ng/mL to 0.62 ng/mL for the study group and 0.78 ng/mL for the treatment group To 0.49 ng/mL, the difference between the two groups was P<0.05, P<0.05 before and after treatment in each group. Conclusion: Metformin combined with Jianpi Huayu Qingre formula can reduce the serum CRP and IL-6 levels.