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目的 :了解硝苯吡啶 (Nifedipine ,NF)对高原急性缺氧的治疗作用。方法 :利用右心导管法对急进高原现场急性缺氧幼猪应用NF前后的血流动力学及血气各时相点的变化情况进行观察。结果 :急进高原现场幼猪应用NF后肺动脉压 (PAP)及肺血管阻力 (PVR)显著下降 (各时相点分别为P <0 .0 5～ 0 .0 1 ) ,心输出量 (CO)及动脉血SaO2 、PaO2 显著升高 (P <0 .0 5～ 0 .0 0 1 ) ;而心率 (HR)、肺动脉楔压 (PAWP)、平均体动脉压 (mSAP)、PH、HCO3- 、PaCO2 变化无统计学意义。结论 :NF可明显降低急进高原现场幼猪的肺动脉压 (PAP) ,提高CO和动脉血SaO2 、PaO2 ,有利于急性缺氧的治疗。
Objective: To understand the therapeutic effect of Nifedipine (NF) on plateau acute hypoxia. Methods: The changes of hemodynamics and the changes of blood gases at different time points before and after the application of NF were detected by acute right heart catheterization in acute hypoxia piglets. RESULTS: Pulmonary arterial pressure (PAP) and pulmonary vascular resistance (PVR) significantly decreased after acute NF (P> 0.05), while cardiac output (CO) And arterial blood SaO2 and PaO2 were significantly increased (P <0.05-0.010); while heart rate (HR), pulmonary arterial pressure (PAWP), mean arterial pressure (mSAP), PH, HCO3-, PaCO2 change was not statistically significant. CONCLUSION: NF can significantly decrease pulmonary arterial pressure (PAP) of young pigs in acute highland plateau and increase the contents of CO and arterial blood SaO2 and PaO2, which is beneficial to the treatment of acute hypoxia.