钩藤碱６０ｍｇ·ｋｇ－１合用双肼苯哒嗪３ｍｇ·ｋｇ－１十二指肠给药，１ｈ时降低清醒大鼠血压２３％，降低高血压模型大鼠血压２８％，降压幅度超过一药单用及等剂量钩藤总碱与双肼苯哒嗪合用的幅度，合并用药可克服单用后药的加快心率作用。双肼苯哒嗪０．８ｍｇ·ｋｇ－１ｉｖ加快心率，增加分钟心肌张力—时间指数，合用钩藤碱１５ｍｇ·ｋｇ－１增强了前药的降压效果，而心率、分钟心肌张力—时间指数未见明显变化。 Rhynchophylline 60mg · kg-1 combined with double hydralazine 3mg · kg-1 duodenal administration, 1h reduced the blood pressure of conscious rats by 23%, reducing blood pressure in rats with hypertension 28%, more than the rate of decrease in blood pressure A single drug and the same dose of rhynchophylline and double hydralazine combined amplitude, drug combination can overcome the single-use drugs to speed up the role of heart rate. Double hydralazine 0.8mg · kg-1iv to speed up the heart rate, increase myocardial tension-time index, combined with rhynchophylline 15mg · kg-1 enhances the prodrug antihypertensive effect, and heart rate, minute myocardial tension-time index No significant change.