Background Chronic kidney disease(CKD) patients are at high risk of atherosclerosis. Structural and elastic changes of carotid artery wall reflect the range and degree of atherosclerosis in peripheral arteries, which can be acquired by ultrasound radiofrequency-data technique automatically and precisely. Methods A total of 66 CKD patients with negative results on routine carotid artery ultrasound examination were enrolled, and 30 healthy physical examinees were selected as controls. Patients were divided into 3 groups according to CKD stage: stage 1-2,stage 3-4 and stage 5. Clinical characteristics and the laboratory results were acquired. Intima-media thickness(IMT) and compliance coefficient(CC) of common carotid artery were measured by ultrasound radiofrequencydata technique(QIMT and QAS). Predictors of IMT and CC were analyzed respectively. Results Among the 66 patients,15 were on stage 1-2, 15 on stage 3-4 and 36 on stage 5 according to e GFR. The common carotid artery IMT(CCIMT)of all the CKD groups except patients on stage 1-2 was significantly increased when compared with controls. The CC of carotid artery significantly was decreased in every CKD group compared with controls. Age and CKD stage were significant predictors of CCIMT and CC in CKD patients(P<0.05). Aging and advanced CKD stage were associated with increased CCIMT(OR=4.855 and 4.969) and decreased CC(OR=32.178 and 14.068). Conclusions Radiofrequency-data technique can detect the small changes of structure and elasticity of carotid artery wall in CKD patients. CKD patients have increased IMT and decreased elasticity of carotid artery compared with healthy subjects. Aging and advanced CKD stage are associated with increased CCIMT and decreased CC. Background Chronic kidney disease (CKD) patients are at high risk of atherosclerosis. Structural and elastic changes of carotid artery wall reflect the range and degree of atherosclerosis in peripheral arteries, which can be acquired by ultrasound radiofrequency-data technique automatically and precisely. Methods A total of 66 CKD patients with negative results on routine carotid artery ultrasound examination were enrolled, and 30 healthy physical examinees were selected as controls. Patients were divided into 3 groups according to CKD stage: stage 1-2, stage 3-4 and stage 5 Intima-media thickness (IMT) and compliance coefficient (CC) of common carotid artery were measured by ultrasound radiofrequency data technique (QIMT and QAS). Predictors of IMT and CC were sequentially analyzed. Results Among the 66 patients, 15 were on stage 1-2, 15 on stage 3-4 and 36 on stage 5 according to eGFR. The common carotid artery IMT (CCIMT) o all of CKD groups except patients on stage 1-2 was significantly increased when compared with controls. The CC of carotid artery significantly was decreased in every CKD group compared with controls. Age and CKD stages were significant predictors of CCIMT and CC in CKD patients Aging and advanced CKD stages were associated with increased CCIMT (OR = 4.855 and 4.969) and decreased CC (OR = 32.178 and 14.068). Conclusions Radiofrequency-data technique can detect the small changes of structure and elasticity of carotid Artery wall in CKD patients. CKD patients have increased IMT and decreased elasticity of carotid artery compared with healthy subjects. Aging and advanced CKD stage are associated with increased CCIMT and decreased CC.