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目的了解不同性别居民尿酸水平与代谢综合征(MS)相关性,判断最合适诊断MS的尿酸切点,为MS的干预提供科学依据。方法于2011年3月采取整群随机抽样方法对江苏省昆山市玉山镇和锦溪镇的4个小区共1 172名常住居民进行问卷调查、体格检查和实验室检测。结果偏相关分析结果表明,男性尿酸水平与腰围、收缩压、舒张压、甘油三酯均呈正相关(P<0.001),与高密度脂蛋白胆固醇呈负相关(r=-0.141,P<0.001),与血糖无相关(P>0.05);女性尿酸水平与腰围、收缩压、舒张压、血糖、甘油三酯均呈正相关(P<0.01),与高密度脂蛋白胆固醇呈负相关(r=-0.180,P<0.001);对不同性别居民尿酸水平进行四分位划分,调整吸烟史、饮酒史、胆固醇、体质指数和年龄等混杂因素后,随着尿酸水平升高,女性发生MS的危险性增大,其中尿酸水平在P25～P50女性居民发生MS的风险性是尿酸水平在P50女性居民发生MS的风险性是尿酸水平在 P50 female residents The risk of MS was 13.20 times that of uric acid level (P = 13.20, 95% CI = 3.35-51.80) in uterus. The uric acid level in males had no significant effect on the incidence of MS. The results of ROC curve analysis showed that female residents diagnosed The best cut point for MS is 284.0 μmol / L. Conclusions Serum uric acid levels can be used as a diagnostic marker for female MS.