目的 :观察米索前列醇用于早期发生的重度妊高征终止妊娠的安全性和可行性。方法 :选择伴有各种严重并发症且发病较早 ,需要终止妊娠的重度妊高征 8例 (孕周 2 6～ 32 + 6 ) ,同期正常足月需引产者 13例为对照组。米索前列醇5 0μg阴道给药 ,依据宫缩情况 3～ 4h重复给药。监测血压、心率、体温、诱发宫缩时间、用药至临产时间及产程。结果 :两组用药前后血压、心率、体温变化均无统计学差异 (P>0 .0 5 ) ,两组均获引产成功 ,妊高征组用药总量及给药次数明显高于对照组 (P<0 .0 0 1) ,但临床经过平稳 ,无副反应。结论 :米索前列醇用于早期重度妊高征的终止妊娠 ,尤其是对不期待活产的病例 ,具有一定的安全性和可行性 Objective: To observe the safety and feasibility of misoprostol for the termination of pregnancy of severe PIH in the early stage. Methods: 8 cases with severe PIH who had earlier onset and needed termination of pregnancy (gestational age 26 ~ 32 + 6) and 13 normal term need-induced labor during the same period were selected as control group. Misoprostol 50μg vaginal administration, according to contractions 3 ~ 4h repeated administration. Monitoring blood pressure, heart rate, body temperature, induced contractions time, medication to labor time and labor process. Results: There were no significant differences in blood pressure, heart rate and body temperature between the two groups before and after treatment (P> 0.05). Both groups had successful induction of labor. The total amount of medication and the number of administration in PIH group were significantly higher than those in control group P <0. 0 0 1), but the clinical smooth, no side effects. Conclusion: Misoprostol is used in the termination of early severe pregnancy-induced hypertension, especially for those who do not expect live birth, which is safe and feasible