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目的 :分析胆固醇与冠心病、脑血栓、脑出血、肿瘤、心脑血管疾病及肿瘤以外的其它疾病的关系。方法 :在 1974,1979,1980三个年份对北京某钢厂三个人群年龄在 18至 74岁 (平均 45 .3岁 )的 4814名男性工人进行了心脑血管疾病的基线调查 ,并测定了血清总胆固醇水平。随访终点为 1993年 ,平均随访 14.5年。将基线血清胆固醇水平按百分数的四分位数法分成四组。采用 L ogistic回归分析方法 ,控制变量为 :年龄、吸烟、饮酒、收缩压、舒张压等变量。结果 :共有 35 1名工人死亡。死亡原因分别是 ,冠心病 40名(11.4% ) ,脑血栓 2 3名 (6 .5 5 % ) ,脑出血 47名 (13.39% ) ,肿瘤 12 7名 (36 .18% ) ,其它疾病 114名 (32 .48% ) .疾病总死亡率与各组胆固醇呈 U 型关系。以最高胆固醇组做参照 ,L ogistic分析结果 :其它胆固醇组冠心病死亡率危险均小于最高组 ,从最低组到次高组发生冠心病的相对危险分别减少了约 75 % (P<0 .0 5 ) ,41% ,2 2 %。对脑血栓而言 ,最高组与最低组没有差别 ,但收缩压、舒张压的相对危险度都为 1.0 2 7,收缩压 P值为 0 .0 48,舒张压没有差别。胆固醇各组与最高组相比 ,脑出血的死亡相对危险度分别是 2 .3(P=0 .0 5 0 6 ) ,1.72 ,1.13;舒张压的相对危险度 1.0 5 8(P<0 .0 1)。其它疾病相?
Objective: To analyze the relationship between cholesterol and coronary heart disease, cerebral thrombosis, cerebral hemorrhage, tumor, cardiovascular and cerebrovascular diseases and other diseases besides tumor. METHODS: Baseline surveys of cardiovascular and cerebrovascular diseases were conducted in 1974, 1979, and 1980 in a group of 4814 male workers aged 18 to 74 years (average 45.3 years) in three groups in a steel plant in Beijing. Serum total cholesterol levels. The end point of follow-up was 1993 and the average follow-up was 14.5 years. Baseline serum cholesterol levels were divided into four groups by the percent quartile method. Using logistic regression analysis, control variables were: age, smoking, alcohol consumption, systolic blood pressure, and diastolic blood pressure. Result: A total of 35 workers died. The causes of death were coronary heart disease 40 (11.4%), cerebral thrombosis 23 (6.55%), cerebral hemorrhage 47 (13.39%), tumor 12 7 (36.18%), other diseases 114 Name (32.48%). The total mortality of the disease was U-shaped with each group of cholesterol. Using the highest cholesterol group as a reference, L ogistic analysis showed that the risk of coronary heart disease mortality was lower in the other cholesterol groups than in the highest group, and the relative risk of coronary heart disease from the lowest group to the second highest group was reduced by about 75% (P < .0, respectively). 5), 41%, 22%. For cerebral thrombosis, there was no difference between the highest group and the lowest group, but the relative risk of systolic blood pressure and diastolic blood pressure was 1.02 7. The systolic blood pressure P value was 0.048, and there was no difference in diastolic blood pressure. Compared with the highest group, the relative death risk of cerebral hemorrhage in each group was 2.3 (P=0.05), 1.72, 1.13; and the relative risk of diastolic blood pressure was 1.058 (P<0. 0 1). Other diseases?