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目的 :研究MCA〔甲氨蝶呤、放线菌素D (更生霉素 )、环磷酰胺〕 /顺铂 (DDP)方案治疗恶性滋养细胞肿瘤的疗效。方法 :回顾性分析中山医科大学附属第一医院 1986年 1月— 1995年 1月间以MAC/DDP方案治疗 6 2例恶性滋养细胞肿瘤患者的疗效、副反应及随访结果。结果 :绒癌的治愈率达 85 2 9% ,侵蚀性葡萄胎10 0 % ;死亡 5例 ,均为晚期绒癌 ;中度毒副反应 7例 ;轻度反应 5 5例 ;患者经 3— 6年随访 ,2例复发 ,再以MAC/DDP方案治愈 ;5例患者治疗后 2— 5年再妊娠分娩 ,母儿健康。结论 :MAC/DDP方案临床疗效较高 ,毒副反应轻 ,可用于高危、耐药及复发恶性滋养细胞肿瘤的化疗
Objective: To study the efficacy of MCA [methotrexate, actinomycin D (cyclodextrin), cyclophosphamide]/cisplatin (DDP) regimen in the treatment of malignant trophoblastic tumors. Methods: Retrospective analysis of the efficacy, side effects and follow-up results of 62 patients with malignant trophoblastic tumors treated with MAC/DDP regimen between January 1986 and January 1995 in the First Affiliated Hospital of Sun Yat-sen University of Medical Sciences. Results: The cure rate of choriocarcinoma was 85 2 9%, the erosive hydatidiform mole was 10%; 5 cases died, all were advanced choriocarcinoma; 7 cases had moderate toxicity; 55 cases were mild; After 6 years of follow-up, 2 patients had recurrence and were treated with the MAC/DDP regimen; 5 patients were treated 2 to 5 years after treatment, and the mother and child were healthy. Conclusion: The MAC/DDP regimen has high clinical efficacy and mild side effects. It can be used for chemotherapy of high-risk, drug-resistant and recurrent malignant trophoblastic tumors.