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目的:探讨早发型重度子痫前期期待治疗的可行性与围生结局的关系,进一步研究早发型重度子痫前期适时终止妊娠的临床意义。方法:回顾性分析2003年1月～2008年1月收治的早发型重度子痫前期病例68例,根据其发病孕周不同分为3组,即A组(孕28～30周)10例、B组(孕30+1～32周)25例、C组(孕32+1～33+6周)33例,比较各组期待治疗及围生儿结局。结果:①早发型重度子痫前期病例发病越早,围生儿死亡率越高(P<0.05)。②3组孕妇并发症发生率差异无统计学意义。③3组期待治疗时间A组>B组>C组,3组间期待治疗时间比较差异有统计学意义(P<0.05)。结论:早发型重度子痫前期病情重,并发症发生率高,围生儿预后差,严格选择病例,在期待治疗过程中应严密监护母体胎儿情况,短时间的期待治疗是可行的,时间为7～14天为宜。
OBJECTIVE: To investigate the relationship between the feasibility of expectant treatment of early-onset severe preeclampsia and the outcome of preeclampsia, and to further study the clinical significance of timely termination of pregnancy in preeclampsia with severe preeclampsia. Methods: A retrospective analysis of 68 cases of early-onset severe preeclampsia admitted from January 2003 to January 2008 was divided into three groups according to their gestational age, namely group A (28-28 weeks pregnant), 10 cases, Twenty-five cases in group B (30 ± 1 to 32 weeks of gestation) and 33 cases in group C (32 + 1 to 33 + 6 weeks of gestation). The treatment and perinatal outcome in each group were compared. Results: (1) The earlier onset of preeclampsia severe preeclampsia, the higher the perinatal mortality (P <0.05). ② The incidence of complications in the third group of pregnant women was not statistically significant. (3) Expectant treatment time in group A There was significant difference in expectant treatment time between group A, group B, group C and group 3 (P <0.05). Conclusions: Premature onset severe preeclampsia is characterized by severe illness, high incidence of complications, poor prognosis of perinatal children and strict selection of cases. In the process of expectant treatment, maternal fetus should be closely monitored. Short-term expectant treatment is feasible and the time is 7 to 14 days is appropriate.