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目的研究谷维素对围绝经期妇女内分泌紊乱的改善作用。方法选取2014年10月-2015年10月海口市妇幼保健院接诊的120例围绝经期患者作为本次研究对象,按随机数字表法分为观察组和对照组,每组60例。对照组给予常规的治疗方法,观察组给予谷维素进行治疗。观察两组患者治疗后雌二醇(E2)、卵泡刺激素(FSH)、黄体生成素(LH)、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇水平及临床疗效。结果治疗后,观察组E2水平为(68.25±8.01)pmol/L,高于对照组[(52.09±7.23)pmol/L];FSH及LH水平分别为(34.12±5.69)U/L及(38.03±10.01)U/L,均低于对照组[(46.10±7.02)U/L、(45.83±11.05)U/L],差异均有统计学意义(P<0.05);观察组总胆固醇和甘油三酯水平分别为(7.56±1.23)mmol/L和(3.02±1.01)mmol/L,均低于对照组[(8.97±2.13)mmol/L、(5.97±1.28)mmol/L],差异均有统计学意义(P<0.05);观察组高、低密度脂蛋白胆固醇水平分别为(2.37±0.52)g/L和(1.80±0.57)g/L,均优于对照组[(2.06±0.51)g/L、(2.15±0.46)g/L],差异均有统计学意义(P<0.05);观察组烦热出汗、失眠、情绪烦躁、心神不宁改善时间分别为(12.09±3.01)d、(14.01±2.10)d、(10.20±2.13)d、(13.09±2.72)d,均小于对照组[(21.03±6.23)d、(19.52±5.10)d、(19.70±6.10)d、(20.17±6.08)d],差异均有统计学意义(P<0.05);观察组总有效率为95.00%(57/60),优于对照组(68.33%,41/60),差异具有统计学意义(P<0.05)。结论谷维素治疗围绝经期妇女内分泌紊乱疗效显著,能够使E2、FSH、LH水平恢复正常。
Objective To study the effect of oryzanol on the improvement of endocrine disorders in perimenopausal women. Methods A total of 120 perimenopausal patients admitted from October 2014 to October 2015 in Haikou MCH were selected as the study subjects and divided into observation group and control group according to the random number table method, with 60 cases in each group. Control group given conventional treatment, the observation group was treated with oryzanol. The levels of estradiol (E2), follicle stimulating hormone (FSH), luteinizing hormone (LH), total cholesterol, triglyceride, high density lipoprotein cholesterol and low density lipoprotein cholesterol in the two groups were observed and the clinical effects were observed. Results After treatment, the level of E2 in the observation group was (68.25 ± 8.01) pmol / L, higher than that in the control group [(52.09 ± 7.23) pmol / L]; the levels of FSH and LH were (34.12 ± 5.69) U / L and ± 10.01) U / L, both of which were significantly lower than those in the control group [(46.10 ± 7.02) U / L, (45.83 ± 11.05) U / L] Triethyl ester levels were (7.56 ± 1.23) mmol / L and (3.02 ± 1.01) mmol / L, respectively, which were lower than those in the control group [(8.97 ± 2.13) mmol / L, 5.97 ± 1.28 mmol / L] (2.37 ± 0.52) g / L and (1.80 ± 0.57) g / L, respectively, which were better than those in the control group [(2.06 ± 0.51 ), g / L, (2.15 ± 0.46) g / L], the difference was statistically significant (P <0.05). The improvement time of fever, insomnia, emotional irritability and unease in the observation group were (12.09 ± 3.01 ), d (14.01 ± 2.10) d, (10.20 ± 2.13) d and (13.09 ± 2.72) d, respectively, were significantly lower than those in the control group [(21.03 ± 6.23) d, (19.52 ± 5.10) d and (19.70 ± 6.10) (20.17 ± 6.08) d], the difference was statistically significant (P <0.05). The total effective rate in the observation group was 95.00% (57/60), which was better than that in the control group (68.33%, 41/60) Significance (P <0.05). Conclusion Oryzanol treatment of perimenopausal women endocrine disorders significant effect, can make E2, FSH, LH levels returned to normal.