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复方利福平注射剂是利福平、异烟肼和吡嗪酰胺三种药物,用磷酸盐缓冲液(pH=7)作溶剂配制而成(浓度均为5%)。该制剂在临床上用于肺结核病灶部位介入治疗,淋巴结核以及皮肤结核湿敷治疗等,疗效较好。为了掌握制剂生产及质量控制,本文对制剂的含量测定方法进行了探讨。
The compound rifampicin injection is a rifampin, isoniazid and pyrazinamide three kinds of drugs, with phosphate buffer (pH = 7) as a solvent preparation (concentration of 5%). The preparation is clinically used for the interventional treatment of pulmonary tuberculosis lesions, lymphatic tuberculosis and skin tuberculosis wet compress treatment and the like, and has good curative effect. In order to master preparation and quality control, this article discusses the determination of the content of the preparation.