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目的探讨血凝集素样氧化低密度脂蛋白受体1与勃起功能障碍(ED)的关系。方法选取我院收治的ED患者60例为病例组,勃起功能正常的健康者60例为对照组,测量其血清血凝集素样氧化低密度脂蛋白受体1、血脂水平并进行比较。结果 ED患者血凝集素样氧化低密度脂蛋白受体1、甘油三酯总胆固醇、低密度脂蛋白和极低密度脂蛋白高于对照组(P<0.05),而高密度脂蛋白低于对照组(P<0.05)。经多元回归分析显示,血凝集素样氧化低密度脂蛋白受体1与ED具有正向联系(OR=2.44,95%CI=1.47～4.06,P=0.001)。结论血凝集素样氧化低密度脂蛋白受体1可作为监控ED患者动脉粥样硬化进展程度的指标,反映人体氧化负荷,以指导相应的治疗措施。
Objective To investigate the relationship between hemagglutinin-like oxidized low density lipoprotein receptor 1 and erectile dysfunction (ED). Methods Sixty cases of ED patients admitted to our hospital were selected as the case group and 60 healthy controls with normal erectile dysfunction as control group. Serum levels of serum agglutinin-like oxidized low density lipoprotein-1 and blood lipid levels were measured and compared. Results The levels of blood agglutinin-like oxidized low density lipoprotein receptor 1, triglyceride total cholesterol, low density lipoprotein and very low density lipoprotein in ED patients were significantly higher than those in the control group (P <0.05), while HDLs were lower than Control group (P <0.05). Multivariate regression analysis showed that blood agglutinin-like oxidized low density lipoprotein receptor 1 had a positive correlation with ED (OR = 2.44, 95% CI = 1.47-4.06, P = 0.001). Conclusion Hemagglutinin-like oxidized low density lipoprotein receptor 1 can be used as an indicator to monitor the progression of atherosclerosis in patients with ED, reflecting the oxidative load of the human body to guide the corresponding treatment.