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目的探讨丙戊酸治疗躁狂症的临床疗效、血药浓度及药物不良反应。方法60例躁狂症患者分别接受丙戊酸钠缓释剂及丙戊酸镁治疗6周,并于服药后1,2,4,6周末使用高效液相色谱法检测丙戊酸血药浓度,以Bech-Rafaelsen躁狂量表(BRMS)和不良反应量表(TESS)观察临床疗效和药物不良反应。结果观察组有效率为80.00%,对照组有效率为76.67%,两组疗效无明显差异,有效病例的血药浓度平均为(77.58±14.45)μg.mL-1,治疗窗范围为50~100μg.mL-1之间。结论丙戊酸能有效治疗躁狂症,血药浓度监测有助于临床安全有效用药。
Objective To investigate the clinical efficacy, plasma concentration and side effects of valproate in the treatment of mania. Methods Sixty patients with mania were treated with sodium valproate sustained-release and magnesium valproate for 6 weeks respectively. The plasma concentrations of valproic acid The clinical efficacy and adverse drug reactions were observed with the Bech-Rafaelsen Mania Scale (BRMS) and the Adverse Reaction Scale (TESS). Results The effective rate was 80.00% in the observation group and 76.67% in the control group. There was no significant difference between the two groups. The average plasma concentration of the effective cases was (77.58 ± 14.45) μg.mL-1, and the therapeutic window range was 50-100 μg .mL-1 between. Conclusion Valproic acid can effectively treat mania, and blood concentration monitoring is helpful for the safe and effective clinical treatment.