论文部分内容阅读
目的探讨贝那普利联用氨氯地平的降压效果以及逆转左心室肥厚、改善心功能的作用。方法将140例原发性高血压伴左心室肥厚患者随机分为贝那普利组(46例)、氨氯地平组(47例)、贝那普利联用氨氯地平组(47例),分别接受贝那普利、氨氯地平、贝那普利加氨氯地平治疗12个月,观察期间定期测量血压,服药前后做超声心动图检查。结果用药后三组血压、超声心动图各指标较用药前变化显著(P<0.05),两单用药组比较各指标差异无显著性(P>0.05),联合用药组与单用药组比较各指标差异有显著性意义(P<0.05)。结论贝那普利联合应用氨氯地平治疗原发性高血压降压效果好,逆转左室肥厚效果好,改善心功能作用明显,不良应少。
Objective To investigate the antihypertensive effects of benazepril combined with benazepril and to reverse left ventricular hypertrophy and improve cardiac function. Methods Forty patients with essential hypertension and left ventricular hypertrophy were randomly divided into benazepril group (n = 46), amlodipine group (n = 47), benazepril combined with amlodipine group (n = 47) , Were treated with benazepril, amlodipine, benazepril and amlodipine for 12 months, during the regular observation of blood pressure, echocardiography before and after taking the test. Results After treatment, the indexes of blood pressure and echocardiography in the three groups were significantly changed (P <0.05), but no significant difference was found between the two groups (P> 0.05). Compared with the single drug group, The difference was significant (P <0.05). Conclusion The combination of benazepril and amlodipine has a good antihypertensive efficacy in treating essential hypertension, reversing the effect of left ventricular hypertrophy and improving cardiac function.