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高胃酸分泌在消化性溃疡的发病机制中占有重要地位。实验证明,组织胺释放后通过对胃 H_2受体的作用而促使胃酸分泌。H_2受体拮抗剂是通过改变组织胺分子侧链中某一基团而合成的一类新药,它具有与组织胺竞争的作用,从而阻断胃的 H_2受体,对组织胺、胃泌素等引起的胃酸分泌有较强的抑制作用,且对乙酰胆硷、稳定胆硷酯、咖啡因、胰岛素、胃窦扩张、假饲以及真饲等刺激所致胃酸分泌均
High gastric acid secretion plays an important role in the pathogenesis of peptic ulcer. Experiments show that histamine release through the role of the stomach H_2 receptors and promote gastric acid secretion. H 2 receptor antagonist is a class of new drugs synthesized by changing one of the side chains of histamine molecules, which has the effect of competing with histamine to block the H 2 receptor in the stomach and inhibit the histamine, gastrin And other causes of gastric acid secretion has a strong inhibitory effect, and the acetylcholine, stable choline ester, caffeine, insulin, gastric antrum expansion, pseudo feeding and real feeding and other stimuli caused by gastric acid secretion are