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G-6-PD缺陷症在我国并不少见,1978～1980年我科收治G-6-PD缺陷症46例及1950～1954年在桂林诊治蚕豆病35例,共81例。陈桂林病例外,41例均用高铁血红蛋白还原试验测定G-6-PD,其结果在30％以下为纯合子,31～75％为杂合子,75％以上为正常值。现报告如下: 一、药物所致溶血:男性8例。年龄45天至14岁。多因呼吸道、消化道疾患就诊。其中2例服痢特灵;1例同服痢特灵、合霉素、氨基比林三药;3例服退热药;1例肌注安热静;1例服熊胆。全部均于进食药物1～2天内出现急性溶血性贫血(平均血红蛋白为5.8克％),酱油样尿,肝脾肿大等。
G-6-PD deficiency is not uncommon in our country. From 1978 to 1980, 46 cases of G-6-PD deficiency and 35 cases of broad bean disease were treated in Guilin from 1950 to 1954, a total of 81 cases. In the case of Chen Guilin, all 41 patients were tested for G-6-PD by methemoglobin reduction test. The results showed that homozygotes were less than 30%, heterozygotes were 31-75% and heterozygote was more than 75%. Now report as follows: First, drug-induced hemolysis: 8 males. Age 45 days to 14 years old. More due to respiratory tract, gastrointestinal disease treatment. Among them, 2 were furazolidone, 1 was furazolidone, tobramycin and aminopyrine, 3 were antipyretics, 1 was intramuscularly safe, and 1 was served with bear bile. All of them were acute hemolytic anemia (mean hemoglobin 5.8g%) within 1 ~ 2 days of eating drugs, soy sauce-like urine, hepatosplenomegaly and so on.