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目的:考察喜炎平注射液与利巴韦林注射液等15种药物配伍后在5%葡萄糖或0.9%氯化钠注射液中的稳定性。方法:室温下,将喜炎平注射液分别与15种药物配伍后,考察配伍后0~6 h内药液的性状、pH值、不溶性微粒、主要成分磺化物E含量的变化情况。结果:配伍液的外观颜色在6 h内无显著变化;注射用头孢唑啉钠和头孢趺辛钠与喜炎平注射液配伍后的pH在6 h内逐渐上升,其他药物配伍后pH无显著变化;喜炎平注射液与15种药物配伍后不溶性微粒数量明显增多,且均超出药典规定;注射用阿昔洛韦和注射用更昔洛韦与喜炎平注射液配伍后主要成分磺化物E含量在6 h内显著下降,其他药物无显著变化。结论:喜炎平注射液在临床上可用5%葡萄糖或0.9%氯化钠稀释静脉滴注,但需严格避免与所述15种药物在同一容器内混合使用。
OBJECTIVE: To investigate the stability of Xiyanping injection combined with 15 drugs such as ribavirin injection in 5% glucose or 0.9% sodium chloride injection. Methods: After compatibility of Xiyanping injection with 15 kinds of drugs at room temperature, the change of drug properties, pH value, insoluble particles and the content of sulfonated substance E in 0-6 h after compatibility were investigated. Results: The appearance color of the compatibility liquid showed no significant change within 6 h. The pH value of cefazolin sodium and cefotaxime sodium injection combined with Xiyanping injection gradually increased within 6 h. The other drugs did not have significant pH after compatibility Change; Xiyanping injection and 15 kinds of drugs compatibility of insoluble particles increased significantly, and are beyond the Pharmacopoeia; injection of acyclovir and injection of ganciclovir and Xiyanping injection after the compatibility of the main component sulfonate E content decreased significantly within 6 h, no significant changes in other drugs. Conclusion: Xiyanping injection can be clinically diluted with 5% dextrose or 0.9% sodium chloride for intravenous infusion, but strictly avoid the 15 kinds of drugs mixed in the same container.