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目的探讨左旋精氨酸(L-Arg)对心肌缺血再灌注损伤(MIRI)的保护作用。方法制备家兔MIRI模型,观察L-Arg对血清中和心肌组织中一氧化氮代谢产物(NOP)含量、乳酸脱氢酶(LDH)活性及心肌细胞形态学变化的影响。结果L-Arg保护组和非保护组比较,血清及心肌NOP明显升高(P<0.05);心肌LDH显著增高(P<0.05),而血清LDH无明显变化;心肌细胞形态学异常改变明显减轻。结论L-Arg通过提高机体一氧化氮水平而保护缺血再灌注损伤的心肌。
Objective To investigate the protective effect of L-arginine on myocardial ischemia-reperfusion injury (MIRI). Methods Rabbit MIRI model was prepared to observe the effect of L-Arg on the content of nitric oxide metabolites (NOP), lactate dehydrogenase (LDH) and the morphological changes of myocardial cells in serum and myocardium. Results Serum and myocardial NOP were significantly increased in L-Arg-treated group compared with non-protected group (P <0.05), while LDH in myocardium was significantly increased (P <0.05), but no significant change was observed in serum LDH. Cardiomyocyte morphology Abnormal changes significantly reduced. Conclusion L-Arg protects myocardium from ischemia-reperfusion injury by increasing nitric oxide level in the body.