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肥胖症与许多代谢性疾病密切相关,而目前尚无治疗肥胖症的理想药物。棕色脂肪组织作为产热器官,可分解代谢脂肪,因而成为治疗肥胖症的重要靶组织。简述棕色脂肪组织的结构及作用,详细介绍了基于棕色脂肪组织治疗肥胖的药物作用靶点,其中具有代表性的有过氧化物酶体增殖物激活受体γ辅激活因子1α、锌指蛋白PRDM16和胎盘特异性蛋白8等,并对利用这些靶点治疗肥胖症的研究进行了综述。
Obesity is closely related to many metabolic diseases, but there is no ideal medicine for the treatment of obesity. As a thermogenic organ, brown adipose tissue can metabolize fat and thus become an important target tissue for the treatment of obesity. The structure and function of brown adipose tissue were briefly described. The targets of drug therapy based on brown adipose tissue were introduced in detail. Representative of them were peroxisome proliferator-activated receptor γ-coactivator 1α, zinc finger protein PRDM16 and placenta-specific protein 8, etc., and the research on the treatment of obesity using these targets are reviewed.