将香豆素衍生物华法令给予带瘤小鼠可减少自发性肺转移数。其作用机制仍未完全了解,但可能与其抗凝血作用无关。因为在给华法令的同时,使已消耗的凝血因子Ⅱ、Ⅻ、Ⅸ和Ⅹ得到恢复后,仍可显著减少肺转移数。另一方面,已发现香豆素类对巨噬细胞具有兴奋作用。最近实验表明:华法令也能促进体内 Administration of coumarin derivative warfarin to mice bearing tumors reduced the number of spontaneous lung metastases. Its mechanism of action is not yet fully understood, but may not be related to its anticoagulant effect. Because at the same time as warfarin administration, consumption of clotting factors II, XI, IX and X was restored, the number of lung metastases was still significantly reduced. On the other hand, it has been found that coumarins have an excitatory effect on macrophages. Recent experiments show that warfarin can also promote the body