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目的探讨分析乳腺腺样囊性癌免疫组化表型与临床特征。方法回顾性分析郑州市第十五人民医院2013年6月—2014年6月收治的24例乳腺腺样囊性癌患者临床资料,对所有患者行光镜观察及免疫组化检测,观察分析患者肿瘤的组化表型和临床特征,同时对患者进行随访获取预后信息。结果 10例乳腺腺样囊性癌均为女性,均因发现乳腺法包块就诊,3例行单纯乳腺切除术,4例行包乳手术,3例实行乳腺改良根治术加腋窝淋巴结清扫术,所研究患者均在治疗后获得随访资料,随访结果显示,所有患者均存活,术后3年出现胸壁复发2例,其余患者未出现远处转移或复发,有46枚腋窝淋巴结被清扫出。10例患者的雌激素受体ER和孕激素受体PR均为阴性表达,有5例患者的Her-2呈-~+的阴性表达,其余5例患者行FISH检测后Her-1(++)无过度表达。除了2例患者的Ki-67为25%的阳性外,其余患者的表达均<10%,在所有患者中,ECD及Bcl-2均为阳性表达。结论乳腺腺样囊性癌具有独特的组织病理学特点,一般不会表达雌激素受体ER和孕激素受体PR及Her-2,然而ECD和Bcl-2常常是高表达,预后良好。
Objective To investigate the immunohistochemical phenotype and clinical features of breast adenoid cystic carcinoma. Methods The clinical data of 24 patients with adenoid cystic carcinoma admitted from June 2013 to June 2014 in Zhengzhou Fifteenth People’s Hospital were retrospectively analyzed. All the patients underwent light microscopy and immunohistochemistry. All patients were observed and analyzed Tumor histological phenotype and clinical features, while patients were followed up for prognostic information. Results All 10 cases of adenoid cystic carcinoma were female. All cases were diagnosed as breast mass by mastectomy. Three cases underwent simple mastectomy, 4 cases underwent inclusion surgery, 3 cases underwent modified radical mastectomy plus axillary lymph node dissection, The patients were followed up after treatment. The follow-up results showed that all patients survived. There were 2 cases of chest wall recurrence 3 years after operation, and no distant metastasis or recurrence occurred in the remaining cases. 46 axillary lymph nodes were dissected out. The estrogen receptor ER and progesterone receptor PR of 10 patients were negative, the expression of Her-2 was negative in 5 patients, the remaining 5 patients were detected by FISH Her-1 (++ No overexpression. Except for 25% positive Ki-67 in 2 patients, all other patients expressed less than 10%. ECD and Bcl-2 were positive in all patients. Conclusions Breast adenoid cystic carcinoma has unique histopathological features and generally does not express estrogen receptor ER and progesterone receptor PR and Her-2. However, ECD and Bcl-2 are often overexpressed and the prognosis is good.