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目的探讨厦门地区不同职业对精子DNA完整性和精子参数的影响。方法将就诊的1509例男性不育患者按照职业分为司机组、计算机工作者组、工人组。将600例正常生育组做为健康对照组。采用SQA-V全自动精子分析仪进行精液常规分析,精子DNA完整性检测采用精子染色质扩散试验(SCD),以DNA断裂指数(DFI)表示。结果司机组、计算机工作者,工人组的精子密度、活动率、前向运动率和DFI与对照组比较差异有统计学意义(P<0.05);司机组和计算机工作者组的精子活动率、前向运动率、精子密度及和DFI与工人组比较差异有统计学意义(P<0.05);4组的精液量、精液pH值差异无统计学意义(P>0.05)。结论司机、计算机工作者和工人可以影响精液质量,从而导致男性不育。
Objective To explore the effects of different occupations on sperm DNA integrity and sperm parameters in Xiamen area. Methods 1509 male infertility patients were divided into driver group, computer worker group and worker group according to occupation. 600 normal fertility group as a healthy control group. Sperm routine analysis was performed with a SQA-V automated sperm analyzer. Sperm DNA integrity testing was performed using the Sperm Chromatin Diffusion Assay (SCD) as indicated by the DNA fragmentation index (DFI). Results The sperm density, activity rate, forward movement rate and DFI in driver group, computer worker group and worker group were significantly different from those in control group (P <0.05). The sperm motility rate in driver group and computer worker group, There were significant differences in forward movement rate, sperm density, and DFI between the two groups (P <0.05). There was no significant difference in semen volume and semen pH between the four groups (P> 0.05). Conclusion Drivers, computer workers and workers can affect sperm quality, leading to male infertility.