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目的 探索超声消融术治疗肝癌门静脉癌栓的可行性。方法 建立兔异种门静脉癌栓模型 ,观察超声消融术体内消融效果和对体外Walker 2 5 6和SMMC 772 1细胞杀伤作用。结果 消融前后 ,门静脉通畅度由 0恢复到 10 0 % ,门静脉压力由 2 3 2cmH2 O降至 14 3cmH2 O。兔存活时间由 1 8h延至 8 0h。体外实验发现超声消融对癌细胞的杀伤作用很强。经超声消融后的Walker 2 5 6细胞接种到大鼠皮下癌生长明显延缓。接种至门静脉 ,肝内癌发生率为 2 8%～ 5 7%。结论 超声消融术能有效消融癌栓 ,同时也能有效杀伤癌细胞 ,但杀伤作用不完全。
Objective To explore the feasibility of ultrasound ablation for the treatment of portal vein tumor thrombosis in hepatocellular carcinoma. Methods A rabbit model of portal vein tumor thrombosis was established. The effects of ultrasound ablation in vivo and killing of Walker 256 and SMMC 772 1 cells in vitro were observed. Results Before and after the ablation, the portal vein patency was restored from 0 to 100%, and the portal vein pressure was decreased from 232cmH2O to 143cmH2O. The survival time of rabbits was extended from 18 hours to 80 hours. In vitro experiments found that ultrasound ablation has a strong killing effect on cancer cells. After subcutaneously inoculated Walker 2 5 6 cells, the growth of subcutaneous carcinoma in rats was significantly delayed. Inoculated into the portal vein, the incidence of intrahepatic cancer was 28% to 57%. Conclusion Ultrasound ablation can effectively ablate the tumor thrombus, but it can also effectively kill the cancer cells, but the killing effect is not complete.