使用四氢香叶醇（ＴＨＧ）作为母体，采用格式反应制备４，８二甲基１壬醇（ＤＩＭＮＯＬ）。研究ＤＩＭＮＯＬ对５氟脲嘧啶和盐酸曲马多渗透离体鼠皮的促进作用。以阿佐恩（Ａｚｏｎｅ）和四氢香叶醇（ＴＨＧ）为对照，ＤＩＭＮＯＬ，ＴＨＧ和Ａｚｏｎｅ对５氟脲嘧啶，分别可使药物渗透系数增加３６７８，４８３０，８２７２倍。而对盐酸曲马多，则分别增加１１３２５，１０９６９，９３０４倍。这些促进剂能增加药物的分配系数的扩散系数值。可以认为这些促进剂的作用方式是影响分配和扩散过程，其中扩散过程是主要因素。 Tetrahydro geraniol (THG) was used as the precursor to prepare 4, 8-dimethyl-1-nonyl alcohol (DIMNOL) by the format reaction. To investigate the promoting effect of DIMNOL on 5fluorouracil and tramadol hydrochloride isolated rat skin. With Azone and THG, DIMNOL, THG and Azone could increase the drug permeation coefficient by 36.78, 4830 and 8272 times for 5fluorouracil, respectively. Tramadol hydrochloride, respectively, an increase of 113.25, 109.69, 93.04 times. These enhancers increase the diffusion coefficient value of the drug’s partition coefficient. It can be considered that the mode of action of these accelerators is to influence the distribution and diffusion processes, of which the diffusion process is the major factor.