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苯噻唑力复霉素为我国创新的抗生素、该药对金色葡萄球菌、结核杆菌有高效。本文报导苯噻唑力复霉素对细菌生物大分子合成和超微结构的影响以及细菌对该药的耐药性与细菌膜屏障的关系。 1、苯噻唑力复霉素对细菌大分子合成的影响:苯噻唑力复霉素(0.5μg/ml)加入金色葡萄球菌209P后可立即而显著地抑制[~3H]一尿嘧啶核替的掺入;对[~3H]一亮氨酸掺入的抑制作用弱且慢;对[~3H]一胸嘧啶核苷的掺入无影响。说明该药抗菌机制主要是抑
Benzthiazurion ADM is an innovative antibiotic in our country, which is highly effective against Staphylococcus aureus and Mycobacterium tuberculosis. This article reports the effects of risindoxythromycin on the biosynthesis and ultrastructure of bacterial macromolecules and the relationship between bacterial resistance to the drug and bacterial membrane barrier. Effect of benzothiazomegacurycin on the synthesis of bacterial macromolecules: Benzothiazole rifamycine (0.5μg / ml) can significantly and immediately inhibit the [~ 3H] -uracil substitution when added with 209P The incorporation of [~ 3H] -leucine was weak and slow; no effect on the incorporation of [~ 3H] -thymidine. The antibacterial mechanism of the drug is mainly suppressed