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目的分析2010-2014年该院分离鲍曼不动杆菌的分布特点及对常用抗菌药物的耐药性变化,为临床治疗提供帮助。方法对2010-2014年该院分离的鲍曼不动杆菌进行鉴定及药敏试验,并利用WHONET5.6软件进行统计分析。结果 2010-2014年共分离出鲍曼不动杆菌772株,这些菌株分别来自痰、尿、血液、胆汁等,以痰标本多见。药敏试验结果显示,鲍曼不动杆菌对多种抗菌药物有较高耐药率,对头孢哌酮/舒巴坦和亚胺培南耐药率较低,对氟喹诺酮类的耐药率上升较快。鲍曼不动杆菌多重耐药菌株分离率逐年上升,2010-2014年分别达33.6%,36.5%,64.6%,54.1%和59.2%。结论鲍曼不动杆菌的耐药情况日趋严重,多重耐药菌株分离率逐年升高,应加强对临床抗生素应用的监管及耐药性监测,以遏制耐药株的增长。
Objective To analyze the distribution characteristics of Acinetobacter baumannii isolated from the hospital in 2010-2014 and the change of drug resistance to commonly used antibiotics to provide clinical help. Methods The Acinetobacter baumannii isolated from the hospital from 2010 to 2014 were identified and drug sensitive test, and the data were analyzed by WHONET5.6 software. Results A total of 772 Acinetobacter baumannii strains were isolated from 2010 to 2014. These strains were from sputum, urine, blood and bile, respectively. Susceptibility test results showed that Acinetobacter baumannii had a higher resistance rate to a variety of antimicrobial agents, a lower resistance rates to cefoperazone / sulbactam and imipenem, and resistance to fluoroquinolones Rise faster. Acinetobacter baumannii multi-drug resistant strains isolates increased year by year, from 2010 to 2014 were 33.6%, 36.5%, 64.6%, 54.1% and 59.2%. Conclusions Acinetobacter baumannii is becoming more and more serious. The isolation rate of multidrug-resistant strains is increasing year by year. Therefore, the monitoring of clinical antibiotic use and monitoring of drug resistance should be strengthened so as to restrain the growth of drug-resistant strains.