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目的探讨细菌以及阴道滴虫感染与宫颈上皮内瘤变(CIN)的相关性。方法选取2013年3月至2015年2月在我院治疗的CIN患者323例,其中CINⅠ患者134例,CINⅡ患者102例,CINⅢ患者87例,同时选取187例正常宫颈上皮女性作为对照,检测各组女性人乳头瘤病毒(HPV)、细菌性阴道病(BV)、沙眼衣原体(Ct)、阴道滴虫感染情况。结果 CIN组患者HPV、BV、Ct、滴虫感染率均明显高于对照组(P<0.05);CINⅢ组HPV、BV感染率分别为86.21%和45.98%,明显高于其他组(P<0.05);CINⅠ、CINⅡ和CINⅢ组Ct、滴虫感染率差异比较无统计学意义(P>0.05);CIN组患者HPV合并Ct、HPV合并BV、HPV合并滴虫的感染率分别为23.53%、20.12%和18.27%,明显高于对照组(P<0.05);Spearman秩相关分析,显示HPV感染与Ct、BV和滴虫感染呈一定的相关性(rs=0.198、0.111、0.158,P<0.05)。结论 HPV感染与CIN病变密切相关,而细菌性阴道病、沙眼衣原体、阴道滴虫感染可能会增加HPV感染,在CIN病变中可能起着HPV感染辅助作用。
Objective To investigate the relationship between bacterial and vaginal trichomoniasis infection and cervical intraepithelial neoplasia (CIN). Methods A total of 323 CIN patients treated in our hospital from March 2013 to February 2015 were selected. Among them, 134 cases were CINⅠ, 102 cases were CINⅡ, 87 cases were CINⅢ, and 187 cases of normal cervical epithelium were selected as control Group of female human papilloma virus (HPV), bacterial vaginosis (BV), Chlamydia trachomatis (Ct), vaginal trichomoniasis infection. Results The infection rates of HPV, BV, Ct and Trichomoniasis in CIN group were significantly higher than those in control group (P <0.05). The infection rates of HPV and BV in CIN group were 86.21% and 45.98%, respectively, which were significantly higher than those in other groups ). The infection rates of Ct and Trichomoniasis in CINⅠ, CINⅡand CINⅢgroups were no significant difference (P> 0.05). The infection rates of HPV, Ct, HPV combined with BV and HPV with trichomoniasis in CIN group were 23.53% and 20.12 % And 18.27%, respectively, which were significantly higher than those in the control group (P <0.05). Spearman rank correlation analysis showed that HPV infection was correlated with Ct, BV and trichomoniasis infection (rs = 0.198,0.111,0.158, P <0.05) . Conclusion HPV infection is closely related to CIN. However, bacterial vaginosis, Chlamydia trachomatis and Trichomonas vaginalis infections may increase HPV infection, and may play an auxiliary role in HPV infection in CIN lesions.