Stereodivergent catalytic asymmetric allylic alkylation (AAA)

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Chirality or handedness, i.e., the non-superimposability of a structure (lacking a plane or center of symmetry) with its mirrorimage, strongly impacts various chemistry/biology areas, and plays an important role, e.g., in materials chemistry [1].In medicinal chemistry it is critical to evaluate the therapeutic and toxicological properties of all stereoisomers of a drug molecule because diastereoisomers and enantiomers may exhibit distinct biologicaland pharmacological activities [2].
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