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背景 由于注射了后来发生了克-雅(Creutzfeld-Jakob)病的供血者的血液成份,因而提出一个问题:血液可能作为医源性疾病的一种媒介。研究设计及方法作者将已感染的仓鼠脑碎组织经胰酶消化的细胞“接种”(Spike)于正常人血,而后试验其血液成分和Cohn血浆组分中的传染性,同时将鼠已适应的人传染性海绵状脑病毒株接种于鼠,其临床发病后检查共血中的传染性。传染性试验用接种血液标本于健康动物的脑内。结果 “接种”的人血中其大部分传染性与细胞性血液成分相关;在血浆中存在传染性较小。当分层时发现传染性主要
Background Due to the blood composition of blood donors injected with Creutzfeld-Jakob disease, a question arises: Blood may serve as a vehicle for iatrogenic diseases. Study Design and Methods The authors “spiked” infected pancreatic digested cells of the infected hamster brain to normal human blood and then tested their blood composition and infectivity in the Cohn plasma fraction while adapting the rat Of human transmissible spongiform encephalitis virus strains were inoculated in mice and examined for co-infection in the cohorts after their clinical onset. Infectious test Inoculated with blood samples in healthy animals brain. As a result, most of the “inoculated” human blood was associated with cellular blood components; it was less infectious in the plasma. Infectious is found mainly when stratified