论文部分内容阅读
阿斯匹林(ASA)仍然是使用最广的抑制血小板药物。在卒中的预防中,加拿大和法国大组病例的研究表明:每天分别给予1.3克和1克阿斯匹林,明显减少卒中的危险性。抑制血小板的环氧化酶需要的 ASA 的剂量远小于1克,但最合适的剂量尚未解决。作者业已证明在脑血管病患者,每天给 ASA25~75毫克长期治疗,能充分抑制血小板聚集。本文目的在于用小剂量 ASA 以延长脑血管病患者的出血时间。
Aspirin (ASA) remains the most widely used antiplatelet agent. In the prevention of stroke, studies in a large group of Canadian and French patients showed that administering aspirin to 1.3 grams and 1 gram each day significantly reduced the risk of stroke. The dose of ASA needed to inhibit platelet cyclooxygenase is much less than 1 gram, but the most appropriate dose has not been resolved. The authors have shown that in patients with cerebrovascular disease, long-term treatment of ASA 25 ~ 75 mg, can fully inhibit platelet aggregation. This article aims to use low-dose ASA to prolong bleeding time in patients with cerebrovascular disease.