逆转录酶抑制剂和蛋白酶抑制剂联用可抑制HIV-1复制,降低病毒载量并减少发病率和病死率,而由于耐药突变病毒株的出现,有时使治疗失败。为了克服这一情况需寻找作用于病毒复制过程中不同位点的高效且毒副作用小的抗HIV-1药物。HIV-1复制过程中有3种必需酶即逆转录酶、蛋白酶和整 The combination of a reverse transcriptase inhibitor and a protease inhibitor inhibits HIV-1 replication, reduces viral load and reduces morbidity and mortality, and treatment sometimes fails due to the emergence of drug-resistant mutant strains. In order to overcome this situation, it is necessary to find efficient and less toxic anti-HIV-1 drugs that act on different sites during virus replication. HIV-1 replication process has three kinds of essential enzymes that reverse transcriptase, protease and whole