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In this paper, the partial stabilization problem for a class of nonlinear continuous control systems with separated variables is investigated. Several stabilizing controllers are constructed based on the partial stability theory of Lyapunov and the property of M-matrix, and some of these stabilizing controllers are only related to partial state variables. The controllers constructed here are shown to guarantee partial asymptotic stability of the closed-loop systems and these sufficient conditions may give some instructions to actual engineering application. A example is also given to illustrate the design method.