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目的 :观察 NIDDM患者视网膜病变 (DR)与 2 4h尿白蛋白排泄率 (UAER)的相关性。方法 :对 138例 NIDDM患者同时进行眼底荧光血管造影 (FFA)及放射免疫法测定 UAER。结果 :糖尿病视网膜病变的发生和严重程度随 UAER增加而加重 ;正常、背景型和增殖型视网膜病变 UAER平均值分别为 9.97± 9.8μg/min、 2 7.0 9± 32 .5 9μg/m in和 6 2 .70±47.6 8μg/m in (P <0 .0 5 )。同样 ,白蛋白尿发生率也随 DR程度的加重而显著升高。结论 :NIDDM患者 DR和 UAER显著相关 ,同时进行 FFA及 U AER的检测 ,对糖尿病肾病的早期诊断有重要价值。
Objective: To observe the correlation between retinopathy (DR) and urinary albumin excretion (UAER) at 24 hours in patients with NIDDM. Methods: UAER was measured by fundus fluorescein angiography (FFA) and radioimmunoassay in 138 patients with NIDDM. Results: The incidence and severity of diabetic retinopathy were aggravated with the increase of UAER. The average values of UAER in normal, background and proliferative retinopathy were 9.97 ± 9.8μg / min, 2 7.09 ± 32.59μg / m in and 6 2 .70 ± 47.6 8 μg / m in (P <0.05). Similarly, the incidence of albuminuria also increased significantly with the severity of DR. Conclusion: There is a significant correlation between DR and UAER in patients with NIDDM and the simultaneous detection of FFA and U AER. It is of great value in the early diagnosis of diabetic nephropathy.