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目的:探讨单纯脑白质疏松症(LA)以及LA合并脑梗死及其MRI影像学严重程度与年龄、性别、高血压、糖尿病相关性初步分析。方法:根据郭氏等2003年制定的LA诊断标准纳入168例脑白质疏松症患者,分为A、B两组:A组95例为单纯脑白质疏松(LA),B组73例为LA合并脑梗死(LA+CI)。两组患者均行头MRI检查。根据Kinkel等的方法将T2WI显示脑室周围高信号范围及程度分为5型。结果:年龄与脑白质疏松的严重程度呈线性相关性(P<0.05),男性与女性间比较脑白质疏松的发生率无显著差异(P>0.05),LA以及LA+CI患者,其高血压及糖尿病伴发率较高,而且LA+CI组高于LA组(高血压P<0.01,糖尿病P<0.01),LA患者MRI表现以1型为主,LA+CI患者表现以2型为主,P<0.01)。结论:脑白质疏松症的严重程度与年龄密切相关,LA的发生率在男女性别间无明显差异。高血压、糖尿病可能是LA的危险因素。LA+CI组与单纯LA组相比,其高血压、糖尿病伴发率更高且MRI表现程度更重。
OBJECTIVE: To investigate the association between simple brain leukoaraiosis (LA) and cerebral infarction with LA and the correlation between the severity of MRI and age, gender, hypertension and diabetes mellitus. Methods: 168 patients with leukoaraiosis were enrolled according to the LA diagnostic criteria established by Kuo et al. In 2003 and divided into A and B groups: 95 cases in group A were pure leukoaraiosis (LA), 73 cases in group B were LA combined Cerebral infarction (LA + CI). Both groups underwent MRI examination. According to the method of Kinkel et al T2WI showed high signal range around the ventricle and the degree is divided into 5 types. Results: There was a linear correlation between age and the severity of leukoaraiosis (P <0.05). There was no significant difference in the incidence of leukoaraiosis between males and females (P> 0.05). LA and LA + CI patients had high blood pressure And diabetes mellitus with high incidence of LA, but also higher in LA + CI group than in LA group (hypertension P <0.01, diabetes mellitus P <0.01). MRI showed mainly type 1 in LA patients and type 2 in LA + CI patients , P <0.01). Conclusion: The severity of leukoaraiosis is closely related to age. The incidence of LA is not significantly different between men and women. Hypertension, diabetes mellitus may be a risk factor for LA. LA + CI group compared with simple LA group, its high blood pressure, diabetes, higher incidence and more severe MRI performance.