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叶酸受体在许多源于上皮组织的恶性肿瘤中高度表达,是目前肿瘤放射性显像研究的一个新的靶点。由于叶酸对于叶酸受体具有很高的亲合性,作为重要的特异性靶向介导分子,99mTc标记叶酸肿瘤显像剂已成为当前放射性药物的研究热点之一。本文对不同类型的99mTc标记的叶酸类放射性肿瘤显像剂的研究进展、应用情况和存在的问题进行了评述,探讨了99mTc标记叶酸显像剂的一般设计方法,并对其未来发展方向进行了展望。
Folate receptors are highly expressed in many epithelial-derived malignancies, which is a new target of tumor radiosurgery research. Since folate has a high affinity for folate receptors, 99mTc-labeled folate tumor imaging agents have become one of the hot topics in current radiopharmaceuticals as an important specific targeting molecule. In this paper, the progress, application and existing problems of different types of 99mTc-labeled folate radioactive tumor imaging agents were reviewed. The general design method of 99mTc labeled folic acid imaging agent was discussed and its future development was also discussed Outlook.