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甘氨酰脯氨酸二肽氨基肽酶（GPDA）是一种存在于人体唾液腺、颌下腺等组织及唾液和血液中的肽链水解酶,该酶能水解肽链N末端的甘氨酰脯氨酸残基,提示在某些疾病时胶原代谢异常可改变此酶活性。已发现肝脏疾病时该酶活力增加,胃癌和胰腺癌时酶活力下降。我院自1992～1994年12月对132例恶性血液病的GPDA活力测定。发现该酶活力对血液病类型鉴别、疗效观察和预后判断有一定指导意义,现总结如下。
Glycyl-proline dipeptide aminopeptidase (GPDA) is a peptide hydrolase present in human salivary glands, submandibular glands and other tissues as well as saliva and blood. This enzyme can hydrolyze the N-terminal glycyl hydrazide of peptides. Acid residues, suggesting abnormal collagen metabolism in certain diseases can alter this enzyme activity. It has been found that the activity of the enzyme increases in liver diseases, and the activity of enzymes decreases in gastric cancer and pancreatic cancer. In our hospital from 1992 to December 1994, the GPDA activity of 132 cases of hematologic malignancies was measured. It was found that the activity of this enzyme has certain guiding significance for the identification of blood diseases, observation of curative effect, and prognosis judgment, and is summarized as follows.