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目的:研究心复康口服液对心衰大鼠心肌乳酸水平的影响,探讨中药改善心肌能量代谢的机制。方法:将75只大鼠随机等分为假手术组(SH)、腹主动脉缩窄模型组(CAA)、心复康口服液治疗组(XFK)。建立模型并检测其心功能参数、心肌乳酸含量。结果:6周、12周时CAA组大鼠心功能明显降低,XFK组较CAA组改善(P<0.01);6周时XFK组、CAA组大鼠心肌乳酸均升高(P<0.01),12周时XFK组大鼠乳酸下降(P<0.01)。结论:心复康口服液对心衰大鼠心功能及乳酸水平有改善。
Objective: To study the effect of Xinfukang Oral Liquid on myocardial lactic acid in rats with heart failure and to explore the mechanism of Chinese medicine in improving myocardial energy metabolism. Methods: Seventy five rats were randomly divided into sham operation group (SH), abdominal aorta constriction model group (CAA) and XFK oral liquid treatment group (XFK). Establish model and test its cardiac function parameters, myocardial lactic acid content. Results: At 6 weeks and 12 weeks, the cardiac function of CAA group was significantly lower than that of CAA group (P <0.01); at 6 weeks, the myocardial lactate of XFK group and CAA group were significantly increased (P <0.01) Lactic acid in XFK group decreased at 12 weeks (P <0.01). Conclusion: Xinfukang Oral Liquid can improve cardiac function and lactate level in heart failure rats.