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高危型人乳头状瘤病毒感染(high risk human papillomavirus,HR HPV)是头颈部鳞状细胞癌发生的一个重要相关因素,特别是原发口咽部、缺少烟酒等危险因素的患者。口咽肿瘤中确认发现HR HPV,以及流行病学病例对照研究明确HR HPV与口咽癌发病风险的关系,已阐明了二者的联系。重点论述口咽癌患者与非口咽癌患者在口腔、喉腔和下咽部位的比较及性行为方式的影响。明确头颈肿瘤的性行为危险因素对未来肿瘤预防是必不可少的,同时以利于理解现有的HPV疫苗对未来头颈肿瘤预防的潜在作用。同时还扩展到性行为作为口咽癌发生的一个危险因素以及其作为HPV暴露标记的作用,强调HR HPV是通过性行为传播到上呼吸消化道,增加HPV相关的口咽癌的发病风险。
High risk human papillomavirus (HR HPV) is an important factor in the pathogenesis of squamous cell carcinoma of the head and neck, especially in patients with primary oropharynx and other risk factors such as alcohol and tobacco. Confirmed HR HPV in oropharyngeal tumors, and epidemiological case-control study to determine the relationship between HR HPV and oropharyngeal cancer risk has been clarified the relationship between the two. It focuses on the comparison of oral cavity, larynx and hypopharynx and the influence of sexual behavior among patients with oropharyngeal carcinoma and non-oropharyngeal carcinoma. A clear risk factors for sexual behavior of head and neck cancer is essential for the future of cancer prevention, while helping to understand the potential role of the existing HPV vaccine in the prevention of future head and neck cancer. It also extends to sexual behavior as a risk factor for oropharyngeal carcinogenesis and its role as a marker of HPV exposure, emphasizing that HR HPV is transmitted through sexual intercourse to the upper respiratory tract and increases the risk of HPV-associated oropharyngeal cancer.