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The kinetochore is structurally composed of four layers. We know that three microtubule-based motor proteins such as CENP-E, dynein, and MCAK are located at the outmost region of the kinetochore. Experimentation of these motor functions betters our understanding of mitotic regulation, and chromosome movements in particular. With real-time studies of chromosome movements in live cells, we hope to illustrate the molecular mechanisms underlying mitotic regulation.