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目的:研究不同感染乙型肝炎病毒血清标志物与乙型肝炎DNA含量的关系及临床意义。方法:采用信号引物能量转移定量聚合酶反应测定血清HBV DNA载量。采用全自动快速微粒子酶免分析检测系统检测。结果:不同HBV DNA载量的血清其病毒含量,HBV DNA载量越高,免疫清除HBV DNA载量相对较低,病毒残留HBV DNA载量较低或无HBV DNA复制。结论:研究显示HBsAg和HbeAg与乙肝病毒含量有一定的关系,在一定程度上反映了病毒的复制状态。另外还表明肝功酶学的2个指标ASTALT与乙型肝炎病毒含量关,可以将其比值作为评估感染乙型肝炎病毒程度高低的依据。
Objective: To study the relationship between hepatitis B virus (HBV) serum markers and DNA content in hepatitis B virus (HBV) and its clinical significance. Methods: Quantitative polymerase chain reaction (RT-PCR) was used to determine serum HBV DNA load. Using automatic rapid particle enzyme immunoassay detection system testing. Results: The serum levels of HBV DNA with different HBV DNA load were higher, the higher the HBV DNA load was, the lower the immune clearance HBV DNA load and the lower residual HBV DNA load or no HBV DNA replication. Conclusion: The study shows that HBsAg and HbeAg have a certain relationship with the content of hepatitis B virus, to a certain extent, reflect the replication status of the virus. Also shows that two indicators of hepatic enzymes ASTALT and hepatitis B virus levels off, you can use the ratio as a basis for assessing the level of infection with hepatitis B virus.