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Gemeprost(16,16-双甲基-反式-△~2 PGE_1甲基酯)商品名ONO-802。mifepristone(RU486)是炔诺酮的衍生物,孕激素受体拮抗剂,它可增加子宫肌层对PG的敏感性,使宫颈软化扩张。Dilapan是一种亲水性聚氨酯合成的宫颈扩张棒,放置2～4小时,可使宫颈扩张8～12mm。为确定单用ONO-802,或Dilapan或RU486与ONO-802合用终止中期妊娠的效果及副作用,以及查明应用RU486后再用PGs是否缩短从开始给PG到流产的时间,对要求终止中期妊娠(12～18周)的98例妇女进行了随机研究,分为3组。Ⅰ组:为58
Gemeprost (16,16-bismethyl-trans-? 2 PGE-1 methyl ester) trade name ONO-802. Mifepristone (RU486) is a derivative of norethindrone, a progestin receptor antagonist, that increases the myometrial sensitivity to PG and causes the cervix to soften and dilate. Dilapan is a hydrophilic polyurethane synthetic cervical dilator, placed 2 to 4 hours, can make the cervix dilated 8 ~ 12mm. To determine the efficacy and side effects of discontinuation of interim pregnancy with ONO-802 alone or in combination with Dilapan or RU486 with ONO-802, and to determine whether PGs after administration of RU486 are used to shorten the time from initiation of PG to abortion, (12-18 weeks) of 98 women were randomized into three groups. Group Ⅰ: 58