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目的:通过对中药引起肝损害病例的分析,对中药引起肝损害的发病机制及防治办法进行探讨。方法:总结近15年来中药引起肝损害的病例共427例,分析中药引起肝损害病例的发生情况、原发病的分布情况及临床特点。结果:中药引起的肝损害的病例占所有药物性肝损害的32.6％,且呈逐年上升的趋势。治疗骨关节病、肾脏疾病、皮肤科疾病的中药最易引起肝损害。引起肝损害的中药以壮骨关节丸、雷公藤和黄药子最为常见。不同的中药引起肝损害的临床特点与发病机制不同。结论:临床应进一步加强中药的合理应用及其肝毒性的研究。
Objective: To analyze the pathogenesis of liver damage caused by traditional Chinese medicine and the prevention and treatment of liver damage caused by traditional Chinese medicine. Methods: A total of 427 cases of liver damage caused by traditional Chinese medicine in the past 15 years were summed up to analyze the occurrence of liver damage caused by traditional Chinese medicine, the distribution of primary disease, and clinical features. RESULTS: The cases of hepatic damage caused by traditional Chinese medicine accounted for 32.6% of all drug-induced liver damages and showed a tendency of increasing year by year. Traditional Chinese medicine for the treatment of osteoarthrosis, kidney disease, and dermatological diseases is most likely to cause liver damage. The traditional Chinese medicines that cause liver damage are Zhuanggu Joint Pills, Tripterygium wilfordii and Dioscorea bulbifera. The clinical features and pathogenesis of liver damage caused by different herbs are different. Conclusion: The clinical application of traditional Chinese medicine and liver toxicity should be further strengthened.