目的　研究口腔疣状癌误诊的原因 ,以提高其临床治疗效果。方法　对 2 0例口腔疣状癌的首次诊断及诊疗过程进行回顾性研究。结果　口腔疣状癌首次临床诊断符合率为 3 5 % ,首次病理诊断符合率为 85 %。常易被误诊为疣状增生、乳头状瘤、牙源性囊肿、牙周炎、慢性唇炎。结论　加强对口腔疣状癌生物学行为多样性的认识 ,掌握不同类型口腔疣状癌的生物学行为特征是提高诊断水平的关键 Objective To study the causes of misdiagnosis of oral verrucous carcinoma in order to improve its clinical effect. Methods The first diagnosis and treatment of 20 cases of oral verrucous carcinoma were retrospectively studied. Results The first clinical diagnosis of oral verrucous carcinoma was 35%, and the first diagnosis was 85%. Often easily misdiagnosed as verrucous hyperplasia, papilloma, odontogenic cysts, periodontitis, chronic cheilitis. Conclusion To understand the biological diversity of oral verrucous carcinoma and to understand the biological behavior of different types of oral verrucous carcinoma is the key to improve the diagnostic level