蛋白Z(Protein Z,PZ)是由Prowse和Esnouf[1]首次从牛血浆中分离出来的一种肝脏合成的维生素K依赖性的糖蛋白,属于丝氨酸蛋白酶抑制物超家族成员。正常成人血浆平均浓度一般在2.5~2.9mg/L,t1/2约2.5d,新生儿血浆水平仅为成人的30%~50%,至青春期达到成人水平[2]。蛋白Z具有多种生物学作用,临床研究发现蛋白Z水平变化与血栓性疾病密切相关。 Protein Z (PZ) is the first hepatic synthetic vitamin K-dependent glycoprotein isolated from bovine plasma by Prowse and Esnouf [1] and belongs to the serine protease inhibitor superfamily. Normal adult plasma average concentration of 2.5 ~ 2.9mg / L, t1 / 2 about 2.5d, neonatal plasma levels of only 30% to 50% of adults, reached adulthood adult level [2]. Protein Z has a variety of biological effects, clinical studies have found that changes in protein Z levels and thrombotic diseases are closely related.