颗粒细胞瘤(granulose cell tumor GCT),属于性索间质肿瘤,呈低度恶行,预后良好,但是晚期容易复发。GCT病因不明,目前研究集中于基因甲基化、染色体微卫星不稳定等方面。以22号染色单体和14号染色三体的异常为多见。治疗以手术为主,但由于GCT有晚期复发的特点,因此,应特别强调足够的化疗疗程及各期患者的终身随访。 Granulocytic tumor (GCT), which belongs to the sex cord stromal tumor, has a low degree of malignancy and has a good prognosis, but it is easy to relapse in the late stage. GCT etiology is unknown, the current study focused on gene methylation, chromosome microsatellite instability and so on. Abnormalities of chromosome 22 and 14 are more common. The treatment is surgery-based, but due to the characteristics of advanced recurrent GCT, special emphasis should be placed on adequate chemotherapy regimens and lifelong follow-up of patients.